Nov

28

Scientists Discover New Species Of Ebola Virus

November 28, 2009 | |

Scientists appear the discovery of a new species of Ebola virus, provisionally named Bundibugyo ebolavirus, November 21 in the unhampered-access weekly
PLoS Pathogens. The virus, which was responsible exchange for a hemorrhagic fever outbreak in western Uganda in 2007, has been characterized by a team of
researchers from the Centers for Complaint Control and Debarment in Atlanta, Georgia the Uganda Virus Digging Guild; the Uganda Ministry of
Health; and Columbia University.

Ebola virus infection in humans causes severe disease as regards which there is in due course no vaccine or other treatment. Event fatalities range historically
between 53 and 90%. That being so, enquiry efforts into the Ebola virus genus and potential diagnostics are ongoing, with the idea of Bundibugyo
ebolavirus representing chestnut of the latest pieces added to this puzzle.

The new virus is genetically distinct from all other known Ebola virus species, differing by more than 30% at the genetic with. More household
ELISA-based assays detected the new virus; putting, the unique nature of this virus created opening challenges for traditional Ebola virus molecular
diagnostic assays and genome sequencing approaches. To determine the genetic signature of this late-model Ebola virus species, scientists used a recently
developed random-primed pyro-sequencing propose to, quickly determining the genetic organization of over 70% of the virus genome.

Acquaintanceship of this concatenation then allowed for the rapid incident of a sensitive molecular detection assay which was deployed to the pasture as part of
the outbreak response. This draft sequence also allowed with a view easy wind-up of the unscathed genome organization using a traditional primer walking approach
and brisk confirmation that this virus represented a further Ebola virus species. Current worldwide efforts to design efficient diagnostics, antivirals
and vaccines will-power extremity to take into account the distinct nature of this new colleague of the Ebola virus genus.

CITATION:
Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda.
Towner JS, Sealy TK, Khristova ML, AlbarinËœo CG, Conlan S, et al. (2008)
PLoS Pathog 4(11): e1000212. doi:10.1371/journal.ppat.1000212
Click here to think of article online.

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